A practical way to synthesize chiral fluoro-containing polyhydro-2H-chromenes from monoterpenoids

• Oksana S. Mikhalchenko,
• Dina V. Korchagina,
• Konstantin P. Volcho and
• Nariman F. Salakhutdinov

Beilstein J. Org. Chem. 2016, 12, 648–653, doi:10.3762/bjoc.12.64

• -fluorohexahydro-2H-chromenes under the developed conditions, the reaction occurs with inversion of configuration. Keywords: chirality; fluorine; halo-Prins reaction; isopulegol; monoterpene; Introduction Recently, we have found that a reaction between para-mentha-6,8-dien-2,3-diol (1) and aromatic aldehydes in